Mouse Phenomics

Snyder Resource Laboratories

Mission

The mission of the Mouse Phenomics Resource Laboratory is to assist researchers and industry in promoting high quality, world-class research by providing support for their own driven in vivo models of interest and by generating additional novel data through the development of new in vivo screens and murine models in the field of acute and chronic inflammation and related chronic diseases.

Key Areas of Research

Intravital and non invasive whole animal imaging

Drug dissemination/location screens

Acute and chronic infectious screens

Acute and chronic inflammatory screens

Murine models of human chronic diseases

Metabolic screens

Specialization/Applications


Intravital and Non-Invasive Whole Body imaging (fluorescent, bioluminescent, radioisotopic & x-ray modalities)

• Drug dissemination/location and clearance

• Bacterial dissemination

• Leukocyte behaviour & localization

• Permeability screens • Cancer development & metastasis

• GI related biology (microbiota tracking, leakiness)

• Bone abnormalities & density

Acute Inflammatory Screens

• Bacterial & chemical induced infection

• Leukocyte recruitment & behaviour

• Permeability measures

Murine Models of Human Chronic Diseases

• Chronic bacterial infections/sepsis

• Serum transfer induced arthritis (K/BxN model)

• TNBS/DSS and AOM/DSS models of colitis and colitis associated cancer

• DTH model

• BMT/chimeric screens

• Access to additional models


Personnel

Björn Petri

Björn Petri, PhD, MSc Scientific Director, Res. Ass. Prof.

Scientific Director of the Mouse Phenomics Resource Laboratory since January 2011, Dr. Petri obtained his PhD (Dr. rer. nat.) in Immunology/Cell Biology and Genetics from the Westfalian Wilhelms-University and the Max-Planck-Institute for Molecular Biomedicine in Münster, Germany. Before he started his studies in the field of Immunology Dr. Petri obtained his MSc (Diploma) in Zoology and Physiology at the Max- Planck-Institute for Heart and Lung Research in Bad Nauheim and the Philipps-University in Marburg, Germany. He can look back at over 15 years of in vivo experience working with rodent models in the field of physiology and immunology.

Between 2007 and 2010 he worked as a Postdoctoral Fellow (AHFMR/AIHS) in the Snyder Institute for
Chronic Diseases where he continued to strengthen his expertise in the field of Immunology and its related research models and imaging techniques.

Select Publications

Ryes J.L. et al., FASEB J 2019 Jan22 (macrophage assoc. colitis including whole body imaging)

Zeng Z. et al., Nat Immunol. 2018 Oct;19(10) (Ab assoc. protection from bact. infection including whole body imaging)

Andonegui G. et al., JCI Insight 2018 May 3;3(9) (sepsis assoc. brain damage including whole body imaging)

Kim J.H. et al., Nat Immunol. 2018 Feb;19(2) (lung inflammation and arthritis model)

Ramachandran R. et al., Mol Pharmacol. 2017 Apr;91(4) (intravital drug screen)

Leung G. et al., Mol. Med. 2015 Dec 9. (GI inflammation including whole body imaging)

Lopes F. et al., Arthritis Rheumatol. 2015 Aug 28. (arthritis model)

Dal-Secco D. et al., J Exp Med. 2015 Apr 6;212(4). (liver inflammation)

Halverson T.W. et al., PLoS Pathog. 2015 Jan 15;11(1). (bacterial skin infection)

Prescott D. et al., Inflamm Bowel Dis. 2013 Mar;19(3). (GI inflammation)

Yipp B.G. D. et al., Nat Med. 2012 Sep;18(9). (bacterial skin infection)

Contact

Dr. Björn Petri, PhD, Research Associate Professor

Department of Microbiology, Immunology & Infectious Diseases
HSC 2868 (lab): (403) 210-6538
HSC 2825 (office): (403) 220-4562
Email: bpetri@ucalgary.ca